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Reduced Acute Toxicity of Antigens in Saline-in-Mineral-Oil Emulsion¹

From the Department of Bacteriology, School of Medicine, University of Pennsylvania, Philadelphia 4, Pa.

Abstract

1. The acute lethal toxicity of Shiga neurotoxin, tetanus toxin, botulinus toxin, ricin and Flexner paradysentery somatic antigen for mice, is materially reduced by the administration of these agents in a saline-in-mineral-oil emulsion.

2. The possible significance of this method of preparing vaccine for immunization procedures is discussed.

Footnotes

¹ The work described in this paper was done under a contract, recommended by the Committee on Medical Research, between the Office of Scientific Research and Development and the University of Pennsylvania.