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Studies on the Relative Susceptibility of Young and of Full-Grown Rabbits to Intravenous Infection with Hemolytic Streptococci¹

From the Department of Pathology, Cornell University Medical College, New York, N. Y.

Abstract

A single intravenous injection of varying amounts of strain N.Y.5 of Streptococcus pyogenes was given to young and to full-grown rabbits. Fourteen of 29 (48 per cent) full grown animals, and 26 of 32 (81 per cent) young rabbits survived the infection for at least one week.

Bacteremia was found 5 hours after the intravenous injection. After 24 hours the blood-cultures were sterile or contained only small numbers of streptococci. Heart-blood cultures taken in rabbits that died within 7 days contained innumerable hemolytic streptococci.

Arthritis occurred in the 26 young and in 12 of 14 full-grown animals that survived the infection. In young animals a greater number of joints was involved.

There is evidence to explain the greater susceptibility of full-grown rabbits to intravenous injections of hemolytic streptococci by the assumption that this age-group had become sensitized to these microörganisms through previous contact with them or with their products.

Footnotes

¹ Aided by a grant from The John and Mary R. Markle Foundation, The Ophthalmological Foundation, Inc. and the Dazian Foundation for Medical Research.