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Use of Refined Serum Albumin As a Nutrient for T. Pallidum

From Lederle Laboratories, Inc., Pearl River, N. Y.

Abstract

Refined serum albumin has been identified as the important nutrient that has previously made animal fluids indispensable in the cultivation of Treponema pallidum. By using liver preparations together with serum albumin, we were able to maintain the spirochete continuously on serum-free media. T. pallidum could be cultivated for a limited number of transfers in media containing choline chloride, niacin, pantothenate, pyridoxine, riboflavin, thiamin, and ascorbic acid as a substitute for liver.