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Antigen-Antibody Reactions in the Salmonella Group

Introduction—Complement-Fixation—Precipitation—Agglutinin-Inhibition—Antigenicity—General Conclusions

From the Department of Bacteriology and Serology, Beth Israel Hospital, New York City

Abstract

Aqueous saline extracts of Salmonella organisms are antigenic. They elicit in rabbits the production of specific O- and H-agglutinins, of precipitins and complement-fixing antibodies. O- and H-agglutinins are similar in strength to those produced by immunization with bacterial cells; complement-fixing substances are somewhat weaker. O-antigens in the extracts are heat-stable, H-antigens are heat-labile as far as antibody production is concerned. While, as a rule, precipitins and complement-fixing antibodies were directed only against O-antigens, complement-fixation with H-antigens was observed in two instances. They involved antigen-antibody combinations that have been recorded previously.