HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Similar articles in this journal Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via Google Scholar Google Scholar Articles by Emmart, E. W. Articles by Seibert, F. B. Search for Related Content PubMed Articles by Emmart, E. W. Articles by Seibert, F. B.

The Effect of Tuberculous and Sensitized Sera and Serum Fractions on the Development of Tubercles in the Chorio-Allantoic Membrane of the Chick

From the Division of Physiology, National Institute of Health, Bethesda, Maryland, and the Henry Phipps Institute of the University of Pennsylvania, Philadelphia

Abstract

1. Electrophoretic analyses were made of the amount of albumin, and alpha, beta, and gamma globulins present in tuberculous, "sensitized," and normal rabbit sera.

2. These whole sera were implanted simultaneously with tubercle bacilli of the A 27 strain on the chorio-allantoic membranes of eight-day-old chicks.

3. The incidence of membranes developing tubercles was calculated and the size and development of the tubercles noted.

4. Under the above experimental conditions, sera, either from rabbits sensitized with a purified tuberculin protein preparation or from tuberculous rabbits, possessed tuberculostatic activities in the chick membrane. Both types of sera had higher gamma globulin contents than sera from normal rabbits.

5. Sera from sensitized rabbits implanted on the chick membrane the day before inoculation with tubercle bacilli also produced partial inhibition in the development of the tubercles in the chick membrane.

Footnotes

¹ Aided by a grant from the Committee on Medical Research of the National Tuberculosis Association.