HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Similar articles in this journal Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via Google Scholar Google Scholar Articles by Weil, A. J. Articles by Farsetta, K. Search for Related Content PubMed Articles by Weil, A. J. Articles by Farsetta, K.

The Serological Types of Shigella Paradysenteriae (Flexner)

II. Types with Dual Primary Antigens—practise of Typing-Discussion

From the Lederle Laboratories, Inc., Pearl River, N. Y.

Abstract

1. Cross testing of numerous strains of Shigella paradysenteriæ (Flexner) with the corresponding immune sera reveals a definite number of patterns of agglutinative behavior. 18 of such patterns have been identified.

2. Analysis of immune sera by absorption permits differentiation between primary and secondary antibody fractions that reflect the antigenic composition of the somatic antigens. The primary antigens characterize a given pattern. Secondary antigens can be labelled by their occurrence as primary antigens in other types.

3. Fourteen primary antigens have been identified.

4. Fourteen types can be characterized by these primary antigens. They are identified with 14 serological entities known from previous work, particularly that of Andrewes and Inman and that of Boyd.

5. These 14 types contain one primary antigen only.

6. Types do occur that have two primary antigens—each one identifiable by its occurrence as type-characteristic antigen in types containing one primary antigen only. 3 types with dual primary antigen are described.

7. A simple classification of Sh. paradysenteriæ is proposed which is based on the identification of primary antigens.

8. Identification of primary antigens is possible and made expedient by the employment of immune sera that have been deprived of their secondary antibody fractions by appropriate absorption.

9. The rapid and economical technic of slide agglutination can be used for this purpose.

10. The results of typing of 136 Flexner strains by slide agglutination are presented.