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The Journal of Immunology, 1944, 48: 29-37.
Copyright © 1944 by The American Association of Immunologists, Inc.
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Quantitative Studies of Sulfonamide Inhibitors

Lowell A. Rantz, William M. M. Kirby and Georgiana Dole

From the Department of Medicine, Stanford University School of Medicine, San Francisco, California

Abstract

1. The effects of peptone, yeast extract, amino acids, glucose, and the temperature of incubation on sulfonamide bacteriostasis have been studied.
2. Variation of the temperature of incubation away from an optimum enhanced sulfonamide action.
3. The antisulfonamide action of peptone and yeast extract was closely related to their ability to improve the environment of the test organism.
4. An increase in the concentration of amino acids resulted in truesulfonamide inhibition.
5. The significance of these results has been discussed.






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