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Analogy Between the Effect of Complement on Sensitized E. Typhosa and the Effect of Tissue Individuality on Sensitized Virus

Department of Bacteriology and Immunology, Washington University School of Medicine, St. Louis, Missouri

Abstract

Studies of the antigen-antibody reactions involving bacteria on the one hand or viruses on the other have led some investigators to the conclusion that the principles governing these reactions differ, depending on the nature of the antigen. In particular, it has been claimed (1–4) that viruses unlike bacteria do not combine with neutralizing antibody in vitro. One of the main arguments in favor of this opinion has been the occurrence of a "dilution phenomenon" with so-called neutral mixtures of virus and antiserum (i.e., resumption of infectivity upon simple dilution). Since this same phenomenon may be observed upon dilution of non-infectious mixtures of pneumococcus and anti-serum (5, 6) in which there is no doubt of an in vitro union between antibody and antigen, this evidence does not seem adequate to question the in vitro union of virus and antibody. Indeed, much of the evidence offered in support of the view that virus and antibody do not combine directly is open to criticism (7, 8).

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				R. W. G. WYCKOFF SOME BIOPHYSICAL PROBLEMS OF VIRUSES Science, February 9, 1945; 101(2615): 129 - 136. [PDF]