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The Effect Produced in Vitro by Vitamin C on the Toxic and Antigenic Properties of Diphtherial Toxin

From the Hygienic Laboratory, University of Michigan, Ann Arbor, and The Oklahoma Agricultural and Mechanical College, Stillwater

Abstract

Diphtherial toxin under limited conditions at pH values which are noninjurious, is inactivated by vitamin C. Evidence supports the view that oxidation of the toxic molecule occurs. Furthermore, toxin-vitamin mixtures are unsatisfactory immunizing agents inasmuch as loss of toxicity is accompanied by a corresponding loss of antigenic properties.