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Dermal Supersensitivity, Heat-Labile, and Heat-Stabile Antibody Against Ragweed in Cattle

Lederle Laboratories, Inc., Pearl River, New York

Abstract

Evidence has been given of:

1) the existence of dermal supersensitivity in cattle to ragweed-pollen,

2) the presence of an agent (reagin) in the serum of such animals that permits passive transfer of supersensitivity, and which is destroyed by heating for 2 hours at 56 C,

3) the production of a neutralizing antibody in cattle experimentally injected with ragweed-pollen antigen, which is not impaired in its activity by heating the serum for 2 hours at 56 C,

4) a similar neutralizing effect can be obtained with the serum of rabbits that had been injected with ragweed-pollen,

5) the sera of immunized cows may also have complement-fixing qualities.

The similarity of these findings to the ones in human allergy has been pointed out, and the implications on our conception of the mechanism of supersensitivity in mammals have been discussed.