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The Journal of Immunology, 1943, 47: 237-249.
Copyright © 1943 by The American Association of Immunologists, Inc.
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Histamine-Protein Complexes: Synthesis and Immunologic Investigation

I. Histamine-Azoprotein1

Norbert Fell, Gertrude Rodney and Donald E. Marshall

From the Research and Biological Laboratories, Parke, Davis & Company, Detroit, Michigan

Abstract

Histamine antigens have been prepared by coupling diazotized p-aminobenzoyl-histamine to various proteins. Hyperimmunization of animals with these compounds produced antibodies that were partially specific for the histamine hapten. The immunized animals displayed a marked degree of resistance to anaphylaxis.

Footnotes

1 A preliminary report on histamine-azoprotein was presented at the Chicago Meeting of the American Association of Immunologists, April, 1941.






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