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Agglutinogen of Hemophilus Pertussis, Phase I, for Skin-Testing

Theoretical Considerations, and a Simple Method of Preparation¹

From the Department of Bacteriology, the School of Medicine, the University of Pennsylvania

Abstract

A simple chemical procedure has been outlined for the isolation of a fraction from H. pertussis which has the following properties:

1. It is antigenic; when injected into rabbits intravenously, it gives rise to agglutinins against H. pertussis in phase I.

2. It absorbs quantitatively agglutinins from H. pertussis antiserum.

3. It is non-toxic, as demonstrated by tests on rabbits and human beings.

4. It has been used successfully as a material for skin-tests for susceptibility to whooping-cough.

5. The agglutinogen may well serve as a means of reinforcing waning active immunity to pertussis.

Footnotes

¹ This work was aided by a grant from the United States Public Health Service.