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Studies on the Specific Mechanism of Serum Sickness

III. PASSIVE SENSITIZATION WITH ANTIBODY CONTAINED IN SERUM SICKNESS CONVALESCENT SERUM

From the Willard Parker Hospital and the Mount Sinai Hospital, New York, N. Y.

Abstract

This report deals with the demonstration of specific transferable antibodies in the sera of patients convalescing from serum sickness. Such serum will be referred to as S.S.C.S.

Spain (1) using the Prausnitz-Kuestner (2) technic succeeded in passively transferring antibodies to horse serum from the blood of one individual "naturally sensitive" to horse serum and from "the blood obtained from another individual who was convalescing from serum sickness." Tuft (3) by the same technic demonstrated skin-sensitizing antibodies in 16 of 25 patients recovering from serum sickness. Tuft did not find adequate correlation of those antibodies with the precipitating or anaphylactic antibody and concluded that they were distinct. Voss (4) demonstrated what he called the anaphylactic antibody in the serum (S.S.C.S.) obtained from individuals convalescing from serum sickness by the production of "inverse anaphylaxis in the human" or a localized form of "passive serum sickness." (5)