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Protection in White Mice with Human Post-Convalescent Serum against Infection with Poliomyelitis Virus (Armstrong Strain). II^1,2,

Abstract

The results of the 28 experiments described in this communication may be briefly summarized as follows:

1. Significant protection was obtained up to 72 hours after the administration of 0.2 ml human post-convalescent serum intra-abdominally to 10-gram mice. Some protection was noted up to 2 weeks after administration of serum. (expts. 18–31 inclusive, charts I and II).

2. When serum was administered following infection, maximal protection was obtained at the 6-hour interval; some protection was apparent at the 96-hour interval although no protection was observed when serum was administered 48 hours after infection (chart IV).

3. There appears to be some direct relation between the dose of serum and the weight (or age) of the mice (chart III).

4. The protection appears to be specific (chart V).

5. Protection appears to be due to absorbed circulating antibody and not to a local neutralizing effect secondary to antibody released by trauma of blood-vessels at the site of inoculation (see text and chart V).

6. Neutralization tests suggest a direct correlation between the amount of neutralizing antibody and the degree of protection (chart VI).

Footnotes

¹ From the Bureau of Laboratories, Michigan Department of Health, Lansing, Michigan.

² Aided by a grant from The National Foundation for Infantile Paralysis, Inc.