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Observations on Spontaneous and Induced Refractoriness to Peptone Shock in Dogs

Department of Pharmacology, Northwestern University Medical School, Chicago

Abstract

The intravenous injection of proteose solutions into dogs results in a reaction (commonly referred to as "peptone shock") which is virtually indistinguishable in symptomatology from that of an anaphylactic reaction produced by the injection of specific antigen into a previously sensitized animal. The two reactions are similar in their symptomatology, and in the underlying mechanisms by which the prominent symptoms are produced. In both reactions the vascular crisis is due to a release of histamine (1, 2), and the incoagulability of the blood, to a release of heparin (3, 4). An anaphylactic reaction, when not fatal, is followed by a refractory state, usually referred to as a desensitization. This is considered to be highly characteristic of anaphylaxis and is often used as a criterion of differentiation from apparently similar reactions. While there is no decisive proof as to the mechanism of anaphylactic desensitization, it is rather generally considered to be due to a binding or saturation of sessile antibodies with antigen.

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