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The Journal of Immunology, 1943, 46: 411-425.
Copyright © 1943 by The American Association of Immunologists, Inc.
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The Use of Mice in the Testing of Antigenic Power of Tetanal Toxoid

Walter L. Koerber and Gertrude E. Mook

From the Biological Laboratories, E. R. Squibb & Sons, New Brunswick, N. J.

Abstract

Mice can be used for the determination of the antigenic power both of liquid and of alum-precipitated tetanal toxoid in place of guinea-pigs. An immunization-period of three weeks insures reproducible results in protective tests against 10 M MLD of tetanal toxin.

A quantitative evaluation of the antigenic power can be effected by the use of dosage-response curves, expressing the antigenic power of various toxoids in terms of a selected standard.






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