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A Comparison of the Antigenic Properties of Staphylococcal Vaccine, Staphylococcal Toxoid, and the Two in Combination

From the Department of Research of The National Drug Company

Abstract

Staphylococcal vaccine has been used for the treatment of staphylococcic infections for many years with varying results. Lately evidence has been presented to show that the stimulation of agglutinins, precipitins and other antibacterial substances is insufficient to protect against infections by toxigenic strains of staphylococcci (1). In recent years staphylococcal toxoid has to some extent superseded vaccine, but although clinical results obtained by the use of this product were more encouraging, it has been found ineffective in the treatment of many forms of staphylococcic infections.

While a combination of vaccine with its homologous toxoid has been suggested, and in soine instances injected together practically no experimental evidence has been presented to show the dual antibacterial and antitoxic stimulation by such a combination and the decrease of humoral antibody during the interval between doses.