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Persistence of Leptospira Antibodies in the Circulating Blood of Patients Recovered One to Over Twenty Years from Weil's Disease

From the School of Medicine, University of Texas, Galveston, Texas

Abstract

Eight individuals who had recovered from Weil's disease from two to over 20 years still had agglutinins for type I Leptospira icterohaemorrhagiae present in their circulating blood in significantly high titer. The average level of agglutinative titer during the active phase of the disease in seven cases was 1:23,000—. The minimal dilution in which agglutination occurred between two and 20 years after complete recovery from the disease was 1:100, while the maximal was over 1:30,000.