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Phenomenon of Local Skin-Reactivity (Shwartzman) to Organisms of the Brucella Group¹

From the Departments of Medicine, Bacteriology and Pathology, Duke University School of Medicine, Durham, N. C.

Abstract

Three strains of Brucella suis, 2 of Brucella melitensis, and 2 of Brucella abortus have been studied for their ability to elicit the Shwartzman phenomenon. Positive results were obtained with 2 Brucella suis strains, when saline supernates after centrifugalizing were used for the skin-preparatory dose, and similarly prepared E. coli material given as the provocative dose.

Ability of material prepared from brucella strains to act as the provocative factor was not demonstrated.

Comparative experiments with material prepared from E. coli as well as from Brucella suis showed that previous vaccination with the homologous organism has no influence upon the production of the Shwartzman phenomenon.

Footnotes

¹ This work was supported in part by the James A. Greene Research Fund and by a grant from the John and Mary R. Markle Foundation.