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Complement Fixation for Lymphogranuloma Venereum and for Psittacosis with Frei Reactions among Pneumonia Patients¹

From Harlem Hospital, Department of Hospitals, New York, N. Y., and from the Littauer Pneumonia Research Fund of New York University College of Medicine

Abstract

Complement fixation with Lygranum antigen occurred with sera from Freipositive patients who showed symptoms of lymphogranuloma venereum infection and with sera from Frei-positive patients who had neither symptoms nor a past history of infection. Eighteen Frei-positive reactors, without manifest disease, were found in one hundred and seventy-five pneumococcic pneumonia patients. Cross complement-fixation reactions have been demonstrated with the antigens of lymphogranuloma venereum and psittacosis viruses. Therefore, for the diagnosis of lymphogranuloma venereum, complement fixation must be corroborated by a positive Frei test. In the absence of a positive Frei test, positive complement fixation with Lygranum antigen may indicate the presence of psittacosis or allied viral infection.

Footnotes

¹ These studies received additional support from the Metropolitan Life Insurance Company, and from Mr. Bernard M. Baruch, Mr. Bernard M. Baruch, Jr., Miss Belle N. Baruch, and Mrs. H. Robert Samstag.

² Littauer Fellow in Pneumonia Research, New York, N. Y.