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Influence of Benzene-Poisoning Upon Streptococcal Infections in Rabbits

I. Benzene-Poisoning and Natural Resistance to Intracutaneous Streptococcal Infection

From the Connaught Laboratories and the Department of Physiological Hygiene, University of Toronto

Abstract

1. Leucopenia of varying degrees of severity was produced in rabbits as a result of repeated injections of benzene.

2. Such rabbits failed to develop a typical local lesion when infected intracutaneously with a hemolytic streptococcus, but died of streptococcal septicemia.

3. The same dose of organisms produced in normal rabbits a progressive local inflammation but no generalization.

4. The breakdown of the natural resistance under benzene-poisoning seemed to be due both to the leucopenia and also to a profound modification in the character of inflammatory response.