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Allergy and Immunity in Tuberculosis

II. Relationship of Tuberculin Cutaneous Reactivity to Experimental Infection in the Guinea-Pig

From the Pediatric Research Laboratory, The Jewish Hospital of Brooklyn, N. Y.

Abstract

Guinea-pigs inoculated with the dissociated human strain H₃₇Ra developed cutaneous sensitivity which reached a peak at four to six weeks and gradually declined, tending to disappear completely twenty-eight to fifty-two weeks after infection.

On reinfection with the homologous strain H₃₇Rv animals with different degrees of cutaneous sensitivity showed no difference in the amount of protection conferred by the primary infection. Those with developing cutaneous sensitivity, peak sensitivity, waning sensitivity and zero sensitivity fared equally well in their resistance to reinfection.