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Antibody Response to Hemoglobin Adsorbed on Aluminum Hydroxide

From the Department of Bacteriology, Medical School, University of Wisconsin, Madison

Abstract

1. Hemoglobin of each species tested—human, sheep, rabbit, dog and guineapigfr³—is adsorbed by aluminum hydroxide.

2. The degree of adsorption is conditioned chiefly by the relative proportions in which the hemoglobin and aluminum hydroxide are mixed, secondarily by the H-ion concentration and the character of the adsorbent (sulfate-containing preparations having less adsorptive capacity than sulfate-free).

3. Human hemoglobin adsorbed on aluminum hydroxide is antigenic in rabbits.

4. Administered in one or more series of small intraabdominal injections adsorbed hemoglobin is a more effective antigen than hemoglobin solution administered in the usual manner.

Footnotes

³ Unpublished work of Antoinette J. Polcin—this laboratory, 1941—demonstrated the antigenicity of guinea-pig hemoglobin adsorbed on aluminum hydroxide.

¹ Wisconsin Alumni Research Foundation Scholar, 1938–39