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The Correlation Between Anatomical Changes and the Allergic State in Tuberculous Guinea Pigs

From the Wm. H. Maybury Sanatorium (Detroit Municipal Tuberculosis Sanatorium) Northville, Michigan

Abstract

The reversal, during the past year, in the long-continued downward trend in deaths due to tuberculosis emphasizes the fact that the medical profession does not have for this chronic disease any positive method of control such as has been applied, for instance, in stamping out diphtheria. Before tuberculosis can be controlled successfully fundamental concepts concerning reactions of the host to the infectious agent must be clarified. Perhaps the most important of these concepts is the relation between the hypersensitive or allergic response and immunity.

In a comprehensive review of the literature upon hypersensitivity in infectious disease Rich (1), after discussing the data presented by numerous experimental workers in this field, states that "... up to the present, hypersensitive inflammation has never been satisfactorily shown to be necessary for the successful operation of acquired immunity at any stage of any infection under any condition whatsoever."