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Increase of Specific and Non-Specific Resistance by the Transplantation of Attenuated Tubercle Bacilli Nodules¹

Abstract

Post-mortem examination revealed that the calves no. 131 and 132, recipients of the 9-day-old nodules showed no specific lesions after having been injected intravenously with virulent tubercle bacilli. In the control calf, untreated before the injection of the virulent bacilli, definite processes of miliary tuberculosis were found in the lungs and the thoracic lymph nodes. In calf no. 10,793 from which the nodules had been removed, there was a very pronounced enlargement of the thoracic and pharyngeal lymph nodes, but specific lesions could not be seen either with the naked eye or under the microscope. The degree of resistance left after removal of the two nodules from calf no. 10,793, which had received 10 cg of the less attenuated I.V.A. vaccine, seemed to be greater than the degree of resistance left in a calf from which a nodule formed by subcutaneous injection of only 5 cg of B.C.G. had been removed.

Footnotes

¹ From the Laboratories of Comparative Pathology, University Milan. The experiments described in detail in this paper were carried on in association with the technician A. Bassi and Dr. G. Massironi through a fund granted by the Forlanini Foundation to the Institute for Antitubercular Vaccination.

² Professor of Bacteriology at Middlesex Veterinary School, Waltham, Mass.