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The Effect of the Amount of Antigen on Antitoxin-Formation During the Primary and Secondary Immunizations

From Department of Health of the City of New York, Bureau of Laboratories, Antitoxin Laboratory, Otisville, New York

Abstract

Groups of rabbits were immunized by two courses of intravenous injections of alum precipitated diphtheric toxoid; the two courses were one or more months apart. One injection after the rest period gave far greater antibody response than could be obtained by the first course of immunization.

During the first course the response of rabbits to different doses of antigens was almost the same but during the second course more antitoxin was formed after the injection of larger amounts of antigens up to 5000 Lf per injection. The rise and fall of antitoxin titers were the sharpest with the largest doses of antigen. The accumulation of stimuli in the group with small doses did not produce as high titers as one single injection of 1000 Lf.