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The Antigenic Structure of Hemolytic Streptococci of Lancefield Group A

XII. Antigenicity of the Type-Specific M-Protein¹

From the Department of Bacteriology, The School of Medicine, University of Pennsylvania, Philadelphia

Abstract

The studies described lead to the conclusion that the M-protein is definitely antigenic even though subjected to drastic methods of isolation and purification. The isolated M-protein is not nearly as antigenic, however, as intact streptococci which are believed to contain a fiftieth or less of their weight as M-protein.

Footnotes

¹ This study has been supported in part by a grant from The Commonwealth Fund.