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Ascorbic Acid and Immunity

III. The Effect of Ascorbic Acid upon the Bactericidal Action of Human Blood^1,2,3,

Abstract

1. Synthetic ascorbic acid injected intravenously into human subjects having a deficiency of ascorbic acid in the serum did not result in an in vitro increase in the bactericidal action of whole blood for coagulase-negative staphylococci.

2. Under similar circumstances, the intravenous administration of ascorbic acid was not followed by a rise in the bactericidal titer of serum for E. coli and E. typhosa.

3. The bactericidal action of normal, human serum is not decreased for E. coli, E. typhosa and Shigella paradysenteriae Flexner when the ascorbic acid is completely oxidized in the presence of small amounts of copper.

Footnotes

¹ Aided by grants from Merck & Co., Inc. and from the Minnesota Medical Foundation.

² Presented in part at the Annual Meeting of the American Association of Immunologists, Chicago, April 17, 1941.

³ From the Divisions of Internal Medicine and Laboratory Service of the University of Minnesota Hospitals and Medical School, Minneapolis.