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Effect of Induced Hypercholesterolemia on Antibody-Nitrogen Production (Pneumococcus Type 2) in Rabbits

From the Medical Research Laboratory, Department of Medicine, New York Post-Graduate Medical School and Hospital, Columbia University, New York

Abstract

It is sometimes assumed that serum- or tissue-cholesterol is related in some fashion to the process of immunity. Borchardt (1) found that in cats the intravenous administration of colloidal cholesterol increased the resistance of the animals to Staphylococcus aureus infection. Recently, Chassin and Bruger (2) demonstrated that after the injections of typhoid vaccine, hypercholesterolemic rabbits showed a higher agglutinin titer against E. typhosa than control rabbits with normal blood-cholesterol. Member, Bruger and Chassin (3) found that the total and ester-cholesterol content of the blood was maintained at normal levels during the early stages of immunization of horses with pneumococci. In the later stages of immunization, however, a significant decrease in these sterols occurred.

In the present investigation rabbits were used. The experiments were devised to determine the effect of cholesterol-feeding upon antibody-nitrogen production in rabbits receiving large amounts of pneumococci.