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Potency-Determination of Antipertussis Serum by the Mouse-Protective Test

From the Biological Laboratories of E. R. Squibb Sons, New Brunswick, N. J.¹

Abstract

Reproducible results may be obtained by the procedure given for conducting the mouse-protective test with antipertussis serum.

This has made it possible to establish a provisional standard unit for use in the evaluation of antipertussis rabbit-serum by the mouse-protective test.

A provisional standard unit is defined as that amount of standard serum which will protect 50 per cent of the mice against 2 MLD of a virulent strain of H. pertussis suspended in 4 per cent gastric mucin.

Antipertussis rabbit-sera may be standardized in terms of a control serum using White's formula.

This method of conducting the mouse-protective test in the potency-determination of antipertussis sera is practical and assays specific protection in terms of provisional units.

Footnotes

¹ Read at the Meeting of the Society of American Bacteriologists at Baltimore, Md., December 29–31, 1941.