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Inhibition of Sulfapyridine in Human Serum, Exudates and Transudates

From the Medical Service, Harlem Hospital, Department of Hospitals, New York City, N. Y., and the Littauer Pneumonia Research Fund of New York University College of Medicine¹

Abstract

1. Various exudates, transudates and sera contain substances which inhibit in vitro the action of sulfapyridine.

2. The concentration of these inhibitory substances varied.

3. The size of inoculum had little effect on the inhibitory action.

4. Prolonged standing did not change the amounts of inhibitor-substance present in three pleural fluids and one ascitic fluid.

Footnotes

¹ These studies received additional support from the Metropolitan Life Insurance Company, and from Mr. Bernard M. Baruch, Mr. Bernard M. Baruch, Jr., Miss Belle N. Baruch, and Mrs. H. Robert Samstag.