HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Similar articles in this journal Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via Google Scholar Google Scholar Articles by Morgan, I. M. Articles by Olitsky, P. K. Search for Related Content PubMed Articles by Morgan, I. M. Articles by Olitsky, P. K.

Immune Response of Mice to Active Virus and to Formalin-Inactivated Virus of Eastern Equine Encephalomyelitis

From the Laboratories of The Rockefeller Institute for Medical Research, New York

Abstract

It has been shown that mice could be immunized by means of a sufficient dosage of formalin-inactivated virus of Eastern equine encephalomyelitis to at least as high a degree of cerebral resistance as that induced by active virus. Cerebral resistance, high at 2 weeks after vaccination of both groups, fell gradually over a period of 6 months; it was once more raised to a high degree by further antigenic stimulus.

Mice vaccinated with a sufficient dosage of formalin-inactivated virus had developed at 2 weeks fully as high a concentration of serum-neutralizing antibodies as mice vaccinated with active virus. The concentration fell in both groups during the following 6 months. At the end of that time, mice injected with a single dose of either active or inactivated virus gave a greater antibody-response than after the initial course of vaccination.

Since each rise and fall of cerebral resistance of vaccinated mice was reflected by similar rise and fall of serum-neutralizing antibody, a correlation has been demonstrated between titer of antibody and degree of cerebral resistance.