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Studies on the Mechanism of the Action of Sulfanilamide

V. On the Dissociation of the Phenomena of Growth-Stimulation and Sulfanilamide-Inhibition of Hemolytic Streptococci

From the Laboratory of Surgical Bacteriology of the Harrison Department of Surgical Research, Schools of Medicine, University of Pennsylvania, Philadelphia

Abstract

Some time ago we reported (1) on the bacteriostatic action of sulfanilamide on hemolytic streptococci in human serum. At that time it was noted that the addition to the serum of small amounts of neopeptone resulted in two effects: 1. There was definite increase in the amount of growth in sulfanilamide-free controls, and 2. there was marked interference with the bacteriostatic effect of sulfanilamide.

We concluded that human serum from defibrinated blood was not a favorable medium for maximal reproductive activity of hemolytic streptococci; that the addition of small amounts of peptone to the serum provided a medium suitable for the active logarithmic multiplication of young streptococci. At the same time, the presence of peptone tended to prevent sulfanilamide from exercising the full effect of which it was capable in peptone-free serum. We were unable to determine whether the growth-stimulating and sulfanilamide-inhibiting effects of peptone were associated or dissociated.