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A Test of the Alternation-("Lattice"-)Hypothesis with Divalent and Trivalent Haptens

From the Evans Memorial, Massachusetts Memorial Hospitals, and the Departments of Immunology and Biochemistry, Boston University School of Medicine

Abstract

A prediction of the alternation-(-"lattice"-"mutual-multi-valence"-"framework") hypothesis that antibody and divalent hapten should precipitate, was tested with a variety of haptens. Unfavorable evidence was obtained; visible precipitation did not occur. In the absence of proof to the contrary, the possibility remains that the precipitation of divalent haptens by antibody observed by others is due to the fact that they were not molecularly dispersed, as Landsteiner originally suggested.

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				W. C. BOYD and J. BEHNKE AGGREGATION IN SOLUTION OF A SYNTHETIC HAPTEN Science, July 7, 1944; 100(2584): 13 - 14. [PDF]