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The Inhibition of the Bactericidal Power of Human and Animal Sera by Antigenic Substances Obtained from Organisms of the Typhoid-Salmonella Group

From the Department of Bacteriology and Immunology of the Harvard Medical School and School of Public Health, Boston, Mass.

Abstract

1. Sera with high titers of bactericidal antibody can be obtained in man and the rabbit by repeated intravenous injections of a purified somatic antigen of E. typhosa.

2. The bactericidal activity of antityphoid immune sera prepared by injection of bacterial cells or the purified somatic antigen of E. typhosa is inhibited by the addition of the somatic antigen. The somatic antigens of S. enteritidis and S. paratyphi B show a similar but less marked effect which is in accord with the antigenic classification of White and Kauffmann. The specificity of this inhibition is further indicated by the failure of an extract of Friedländer's bacillus, type A to exert any effect on the bactericidal activity of the immune sera.

Footnotes

¹ John Ware Memorial Fellow