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Further Studies in Passive Protection Against the Virus of Influenza by the Intranasal Route

From the Department of Pediatrics, School of Medicine, University of Pennsylvania, and the Children's Hospital, Philadelphia, Pennsylvania

Abstract

1. The intranasal instillation of anti-influenza A serum protects mice against subsequent infection with heterologous as well as homologous strains of influenza A virus but not against influenza B virus. Anti-B serum affords protection against the influenza B virus but not against the various A-strains tested.

2. The occasional failure of protection after intranasal administration of the serum under ether anesthesia has been overcome by a spraying technic. The inhalation of immune serum droplets led to more uniform results.

3. While the passive immunization experiments showed encouraging results in mice, ferrets were not equally well protected. Fever and nasal symptoms could not be prevented by the intranasal serum dose but pulmonary involvement was markedly reduced. Possible reasons for such differences are discussed.