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Fractionation of a Type 1 Strain of Group "A" Hemolytic Streptococci¹

From the Department of Medicine, College of Physicians and Surgeons, Columbia University, and the Presbyterian Hospital, New York City

Abstract

1. Proteic fractions were isolated from a type 1 strain of hemolytic streptococcus by grinding and extracting undried cells in the cold. One of the most active fractions was sub-fractionated by means of sodium chloride.

2. The serological activity of the fractions was determined by quantitative precipitin-tests.

3. Tryptic digestion of streptococcal proteins indicated the serological activity to be in large part due to difficultly digestible or possibly non-proteic components which appear to be major antigens or haptens of the cell.

4. The presence of C-substance in protein and protein-digest fractions was regularly encountered and its importance in the reactivity of fractions toward antisera emphasized.

Footnotes

¹ The work reported in this communication was carried out under the Harkness Research Fund of the Presbyterian Hospital.

² Fellow of the Norwegian Malthe and Pasteur Foundations, 1939–40; Commonwealth Fund Fellow, 1940–41.