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Studies on the Histamine-Content of the Blood and Tissues of the Rabbit During Anaphylactic Shock

From the McGill University Clinic, Royal Victoria Hospital, Montreal, Canada

Abstract

1. During acute anaphylactic shock in the rabbit, there occurs a marked decrease in the blood-histamine, a lesser decrease in the plasma-histamine and a leucopenia.

2. There does not appear to be any correlation between these changes and the symptoms of anaphylaxis.

3. There is a decrease in the histamine-content of the lung and spleen of the rabbit following the production of anaphylactic shock.

4. In non-sensitized rabbits, there is little or no change in the histamine-content of the blood following the intravenous injection of horse serum. A leucopenia may occur. When egg albumin is injected intravenously, however, a decrease in both the blood-histamine and the white blood count occurs.

5. Histamine-shock in the rabbit is characterized by a moderate decrease in the histamine-content of the blood and a marked increase in the histamine-content of the plasma. A moderate leucopenia also occurs. These findings then differ from those which occur in anaphylactic shock in this species.

6. By superimposing anaphylaxis on histamine-shock in the rabbit, it may be shown that not only is the histamine-content of the blood diminished, but that there is also some mechanism for the removal of large amounts of histamine from the plasma. It is also shown that a sudden increase in the plasma-histamine may occur under these circumstances.

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				P. P. VAN ARSDEL Jr. and G. N. BEALL The Metabolism and Functions of Histamine Arch Intern Med, November 1, 1960; 106(5): 714 - 733. [Abstract] [PDF]