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Passive Immunization against Experimental Infection of Mice with Influenza A Virus: Comparative Effect of Immune Serum Administered Intranasally and Intraabdominally

From the Laboratories of the International Health Division of the Rockefeller Foundation, New York

Abstract

Immune serum administered intranasally was much more effective in preventing pulmonary infection with influenza A virus in mice than a proportional amount of immune serum injected intraabdominally. The protective action of the immune serum intranasally introduced was demonstrated for at least 48 hours following its administration.

Although mice receiving 30 MLD of virus were protected when immune serum was given intranasally within 6 hours, consistent protection against death could not be achieved if the instillation of the serum was delayed for 24 hours after inoculation of the virus.

The manner of action and possible use of intranasally administered immune serum have been briefly discussed.

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