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Effect of Histaminase Pretreatment on Histamine Shock in Guinea Pigs

From the McGill University Clinic, Royal Victoria Hospital, Montreal, Canada

Abstract

In a previous paper, Karady and Browne (1) reported that histamine shock in guinea pigs could be markedly reduced in intensity if the animals were first treated with histaminase intravenously. The following method was used: Of thirty guinea pigs weighing from 250 to 300 grams, twenty were given 3 units of Torantil (T. 360) into the exposed jugular vein under light ether narcosis. In fifteen minutes when they had fully recovered, an injection of 4.0 mg of histamine was given intraabdominally. Ten control animals were injected with the same dose of histamine at the same time. Of the pretreated group 4 developed shock within twelve to fifteen minutes and only two died within thirty-five minutes. The remaining animals showed few symptoms. Out of the 10 control guinea pigs, 7 died within 10 minutes. From these findings, it was deduced that histaminase had a definite effect in vivo on histamine shock.