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Strain-Specificity of Complement-Fixation with Sera of Mice Immune to the Virus of Influenza A and Swine Influenza¹

From The Research Laboratory of the California State Department of Public Health, Berkeley, California

Abstract

The sera of mice immunized with human and porcine strains of influenzal virus exhibit strain-specificity by complement-fixation in that the titer is almost always higher with the homologous antigen.

The antigen-antibody curves for human and porcine influenzal antigens prepared from infected mouse-lungs and tested against immune mouse serum differ in form.

The strain-specificity observed with complement-fixation is less definite than that found by neutralization tests with the same samples of mouse serum.

The serum of human beings convalescent from influenza does not show strain-specificity by complement-fixation.

Footnotes

¹ The studies and observations on which this paper is based were conducted with the support and under the auspices of the International Health Division of The Rockefeller Foundation and in cooperation with the California State Department of Public Health.