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An Electrophoretic Examination of Digested Sera

From Lederle Laboratories, Pearl River, New York

Abstract

A series of electrophoretic and chemical analyses has been carried out upon peptic digests of diphtheric and tetanal antitoxins and upon these antitoxins heated under similar conditions in the absence of pepsin. The results of these analyses show that the first step in antitoxic digestion is the disappearance of albumin and a replacement of T by a new "" component. Prolonged digestion leaves this "" unaffected but reduces the amount of other, electrophoretically inhomogeneous, material in the digest. Similarly digested pneumococcal antiserum did not develop a ""-peak; though it retained a considerable precipitative titer it had lost almost all its mouse-protective capacity.