HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Similar articles in this journal Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via Google Scholar Google Scholar Articles by Johlin, J. M. Articles by Rigdon, R. H. Search for Related Content PubMed Articles by Johlin, J. M. Articles by Rigdon, R. H.

The Detoxification of Staphylococcal Toxin by Adsorption on Organic Liquids

From the Departments of Biochemistry and Pathology, Vanderbilt University School of Medicine, Nashville, Tenn.

Abstract

The hemolytic and dermonecrotic activity of staphylococcal toxin is rapidly and progressively decreased by adsorption on emulsified ether or chloroform and the toxin becomes progressively less soluble as the treatment by adsorption is continued. The process of denaturation, taking place under the influence of surface catalysis, is probably similar to that which takes place spontaneously at a slower rate when the toxin is allowed to stand. The behavior of the toxin after adsorption gives no indication that it contains more than one toxic factor. When the toxin is completely detoxified by prolonged treatment, it appears to retain some of its antigenic properties but is a poor antigen when used according to established procedures.