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Further Studies of the Orientation of Reactive Sites in Thin Films of Streptococcal Antigens¹

Eldridge Reeves Johnson Research Foundation, University of Pennsylvania, Philadelphia

Abstract

Films of the streptococcal derivatives NPA and P₆, when allowed sufficient opportunity for expansion, exhibit significant differences in reactivity of the two film-faces toward homologous and heterologous antisera. When expansion is incomplete the facial differences are largely obliterated.

Variations in the ratios (AB/A), over a wide range of substrate-pH, indicate the presence of at least two types of reactive site which behave independently. Qualitatively, P₆ and NPA films exhibit the same properties; therefore nucleic acid appears to contribute nothing to the serological reactivity of the materials which actually enter into the film-structure.

Footnotes

¹ With the support of a grant from the Johnson Fund of the American Philosophical Society.

² Nemours Foundation Fellow.

³ Commonwealth Fund Fellow.

⁴ Research Assistant, Department of Bacteriology, University of Pennsylvania School of Medicine. Study of the streptococcus in the Department of Bacteriology is supported by a grant from the Commonwealth Fund.