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The Journal of Immunology, 1941, 40: 449-458.
Copyright © 1941 by The American Association of Immunologists, Inc.

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Nonspecific Flocculation of Scarlet-Fever Toxin and Antitoxin

William Edward Bunney and Walter L. Koerber

E. R. Squibb and Sons Biological Laboratories, New Brunswick, New Jersey

Abstract

Evidence of the non-specific character of the scarlatinal toxinantitoxin flocculative reaction is presented. The formation of non-specific antibodies in the horse seems to parallel that of a specific scarlet-fever antitoxin during immunization with toxin containing specific and non-specific antigens. A possible explanation is given as to why the flocculative reaction can be used for evaluating antitoxic titers, whereas doubtful results may be obtained in the determination of toxin-flocculation values.







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