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Studies of the X Strain (Dyer) of Rickettsia Burneti

II. Guinea Pig Infections, with Special Reference to Immunological Phenomena¹

From the Virus Department, Walter and Eliza Hall Institute of Research in Pathology and Medicine, Melbourne

Abstract

1. Fatal infections of guinea pigs with the X rickettsia can be produced with regularity if a large enough dose is given. Enormous numbers of rickettsiae are present in the tissues of guinea pigs dying from the infection within twelve days.

2. Guinea pigs of standard size (around 250 g) give more regular febrile responses than younger or older animals.

3. The administration of immune serum with rickettsiae reduces or annuls the febrile response, but in all instances the animals used are completely immune to a subsequent test-injection.

4. Killed rickettsiae can be used to produce a substantial immunity in guinea pigs. With a single small dose a subsequent immunity-test may result in a modified febrile reaction.

5. The inoculation of guinea pigs with rickettsiae treated with sodium lauryl sulphate solution gives rise to responses closely resembling those obtained with serum-rickettsiae mixtures.

Footnotes

¹ Work carried out under grants for research on viral diseases from the National Health and Medical Research Council, and from Mr. E. Alec Cato.