HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Similar articles in this journal Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via Google Scholar Google Scholar Articles by Rocha E Silva, M. Search for Related Content PubMed Articles by Rocha E Silva, M.

Concerning the Mechanism of Anaphylactic and Tryptic Shock

From the Instituto Biologico, São Paulo, Brazil

Abstract

Recently, we have described the effects produced by trypsin upon the mammalian smooth muscles (guinea-pig intestine, guinea-pig uterus, rabbit, cat and dog intestines, virgin uterus of the rat and mouse intestines (1–3)), as well as the circulatory effects produced in rabbits, cats and dogs by trypsin injected intravenously (2, 4). In experiments of perfusion of guinea-pig lungs we have demonstrated the ability of trypsin to liberate histamine from the tissues, and suggested that this may offer a basis for understanding the pharmacological effects of trypsin (4). The constancy of the phenomenon of "desensitization" observed on repeated additions of the same small dose of trypsin strongly suggested that the action of trypsin was an indirect one, probably through the intermediary of a tissular active substance—histamine—set free under the action of the ferment.

Footnotes

¹ Fellow of the John Simon Guggenheim Memorial Foundation.