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The Rate of Complement-Formation in Dogs

The May Institute for Medical Research of the Jewish Hospital, Cincinnati, Ohio

Abstract

Acute removal of from 50 to 83 per cent of circulating complement has been accomplished by repeated bleeding and replacement of the blood with washed cells and inactivated plasma or washed cells plus acacia and saline.

A restitution of the complement-titer to the normal level occurs in from 14 to 66 hours. In the majority of experiments this occurred within 24 hours.

No quantitative relationship between the rates of formation of serum-proteins and of blood-complement could be demonstrated.