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The Effect of Reducing Agents on the Fourth Component of Complement¹

From the Institute of Pathology, the Department of Pharmacology and the University Hospitals of Western Reserve University, Cleveland, Ohio

Abstract

Reducing agents such as HCN, alkali cyanides, sodium bisulfite and thioglycollic acid fail to inactivate the fourth component of serum-complement. This failure of the cyanide and the bisulfite is in agreement with previous observations made on the reactions of reducing agents and aldehydes; these observations having been variously explained by the protective influence of redox structure, rate of reaction, and dissociation effects.

NaCN and KCN in sufficient concentration inactivate the third component.

Footnotes

¹ Aided by a grant from the Commonwealth Fund.