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Passive Immunization of Mice Against Human Influenza Virus by the Intranasal Route

From the Department of Pediatrics, School of Medicine, University of Pennsylvania, and The Children's Hospital of Philadelphia

Abstract

1. The intranasal injection of anti-influenzal serum under slight ether anesthesia completely protected mice against as much as 100 MLD of human influenza virus and permitted some of them to survive as much as 100,000 MLD. Mouse, ferret, horse, rabbit and human immune sera were found to be effective.

2. A comparison of the intranasal with the intravenous and intraabdominal routes showed that less serum was necessary to protect by the intranasal route than by the others. The length of time protection lasted was shorter after intranasal administration (up to ten days), than after intravenous injection (up to 3 weeks), the duration depending on the amount of virus used for the test dose and the source of the serum.

3. The beneficial effect of immune serum in the treatment of infected mice could be detected only when it was injected within 24 hours after infection. In such treatment the intranasal route appeared to be slightly inferior to the intravenous and intra-abdominal routes.